Four astronauts have their lives changed forever, when they end up being hit by a cloud of cosmic radiation. Reed Richards (Gruffudd) now has the ability to stretch his body like elastic. Sue Storm (Alba) is now the invisible woman. Johnny Storm (Evans) becomes the human touch and Ben Grimm (Chiklis) becomes the 'Thing', a man made out of rock. But there is one problem. The journey's sponsor, Victor von Doom (McMahon) has also been affects and with full power, is a dangerous force which needs to be stopped, before it's too late.